In recent years, the expansion of Iran's nuclear power has been a threat to the Zionist regime's nuclear monopoly in the West Asian region, so the regime has used all its power to prevent Iran's nuclear activity. Therefore, the future outlook of Iran's nuclear activity and file in confrontation with the Zionist regime plays a significant role in preventing this regime's actions against Iran's nuclear power. Therefore, the present study was developed with the aim of identifying the strengths of Iran's foreign policy for the future outlook of Iran's nuclear activity. This study was conducted using a qualitative method in the form of content analysis using the theory of zero-sum games, Nash equilibrium, and saddle point. In this article, library tools were used to collect information in the field of research. In this study, four key and effective factors in foreign policy for the future outlook of Iran's nuclear file in confrontation with the Zionist regime were identified, then by analyzing the calculated factors, it was determined that Iran's game with the Zionist regime is a zero-sum game and Iran is the winner of this game. The findings of this study indicate that Iran's foreign policy on the nuclear issue has been successful, despite the terrorist and subversive actions of the Zionist regime, and Iran has been able to defend its legitimate nuclear right through resistance; as a result, from a prospective perspective, Iran and the Zionist regime will never be able to reach an agreement on the nuclear issue.